Why you don't use a spreadhseet as a database
How many time have we said it: EXCEL IS NOT A DATABASE.
It a wonderfully, full function spreadsheet. It handles spreadsheet data. It does it well, and for most people it is pretty inuitive. I normally bash Microsoft, but Excel is very good.
But it is not a data storage or data transfer tool. We have very good databases (SQL Server or Access if you want to stick with Microsoft - other databases are available).
So, Scientists, use a tool suitable for the job and stop whining when you use a hammer to crack a peanut and your peanut goes to dust.