Re: That opening nose is THE selling point of that freighter
No, it would cost tens or maybe even hundreds of millions of $ to restart the 747 production line once it is shut down, even if the buildings involved were not repurposed or torn down. You'd need to restart production at all the parts suppliers, train a new generation of 747 production workers, refresh all the production equipment and systems, get all that audited/inspected/approved so that the new-generation 747s would be certified as airworthy, etc.
It wouldn't be worth it to Boeing, unless cargo carriers were willing to pay through the nose (no pun intended) for their new 747s.