Re: It's not clear how fully accurate AlphaFold's predictions are.
AlphaFold was already pretty good at CASP13, then blew everybody else out of the water at CASP14. CASP15 is in progress right now.
Part of the problem is that experimentally determining a protein’s folded structure is very laborious, which is why so few are actually known.
What I find impressive is that DeepMind has achieved in a few months in its own lab what Rosetta@home has got nowhere near to in fifteen years with a worldwide distributed network…