"Unfortunately, ... the most popular supported programs on Wine are games."
This, I found, was the problem. They concentrated on performance for gaming at the expense of H/W portability. In particular they deliberately assumed display drivers reporting 24-bit pixels would handle 32-bit because they preferred word alignment. It led to a lot of bug reports where applications would crash on commodity H/W with Intel video.
As they regarded it as a feature the reports went unaddressed which didn't stop them sending out automated emails when new versions were released asking if it had been fixed yet. I kept recompiling new versions with a simple patch until (a) I got fed up, (b) the application I was interested in stopped using a 32-bit splash screen which was the only bit that caused the crash.