@deegee
I use Linux (Ubuntu Intrepid) exclusively on my laptop to get everything done. The only problems I've encountered are:
No Photoshop. VMWare mends the odd occasion I need it
No Dreamweaver: Sometimes a client demands I use DreamWrecker, VMWare again
Open Office not so keen on docx files: Request a PDF version, Office in VMware would be a waste of disk space.
None of these are show-stoppers by any means. Everything else works fine, e.g. FF3, Thunderbird, Skype, Aptana, Spotify...
People go on about Open Office not cutting the mustard and, while not a heavy spreadsheet user, docx is the only problem I have with it which I believe is exactly WHY MS created that format in the first place, isn't it?