'rather than "almost all known protein structures" -- which we already know'
Umm, no. We don't. The very next bit of the article is " - more than 200 million in total." and we certainly don't know 200 million protein structures. As I understand it, in the early days people used to sanity-check AlphaFold's predictions quite thoroughly. Perhaps not spending "years" on X-ray crystallography but certainly some substantial time. As the community slowly got used to the idea that "damn, the blasted computer is always right", the checking has become less and less. Nowadays, it is often omitted because frankly researchers can't justify spending time or money on something that is very unlikely to produce a surprise. Also, anyone who does check the result is going to be beaten by others to the interesting consequences.
In short, then, AlphaFold and its ilk have transformed this area of biology by being a magic box that produces protein structures in minutes which are as accurate as the ones you could produce in several years by traditional methods (and even that's assuming the protein actually exists in Nature to be X-rayed).
Odd that they've got the Chemistry prize for it though, since the (sole?) application is clearly to Biology and Medicine.