Depending upon the AFA, there are other value props for leveraging the technology than just performance. Some incorporate the promise of what DataDomain wanted to do prior to EMC buying them - inline dedupe and compression, etc. This makes them very space efficient which in turn impacts power, data center footprint, etc. You can buy X amount raw but get X*3-5 usuable. There is management as well. There are some neat implementations of how you manage these systems. Others not so much though.
I see the workloads for these being OLTP. Those apps drive the business. And from a vendor perspective, that is where the money is. VDI and VMware a good plays, but OLTP is where they should play. To the author's point, how enterprise ready are the AFAs? Replication is key but there are alternatives - namely app level replication for OLTP (DataGuard, etc.). That said to be truly enterprise ready, they need true sync and async replication with consistency groups.