"they'll switch off as soon as reality TV reaches them!"
Didn't stop the Grebulons (ref. HHGG Mostly Harmless)
2730 posts • joined 24 Mar 2010
.. for a while now I've been using a bash script to control the charging of a laptop.
Script monitors the limits set for chsrge/low charge - signals one of the house pis equipped with remote control board that can turn (4) on/off mains sockets - laptop thus kept within limits. Anyone care to suggest what the limits should be ?? . I'm using 55%-85% at the moment so that there is a reasonable reserve for off-mains running. Of course you need a scripted way of turning off charging before hibernation etc.
Using this on an older laptop has kept the battery capacity at 96% after 4 years.
If you have a spare pi the remote sockets are useful for all sorts of things and very cheap
"Oddly enough, once the protein's been made it doesn't need AI. It just folds itself."
It's an analogue computer of great power. Seriously the most important property of a sequence is to fold quickly and cleanly. The efficiency of it active or whatever is a secondary requirement.
"Determining the structure of the virus proteins might also help in developing a molecule that disrupts the operation of just those proteins, and not anything else in the human body."
Well it might, but predicting whether a 'drug' will NOT interact with any other of the 20000+ protein in complex organisms is well beyond current science. If we could do that we could predict/avoid toxicity and other non-mechanism related side-effects & mostly we can't.
" I'd expect that they already plenty of lot of known proteins that are shared between the new virus and other known Coronavirus strains."
Ditto I was reading this paper yesterday (mainly for its MHC * content) :
The spike protein is thought to be the key to binding to cells via the angiotensin II receptor.
* Old research interest of mine. Part of the major mechanism the immune system uses to distinguish self from non-self
"Nearly $3000 for the test I read."
I believe in Switzerland it's ~ 200CHF so $3000 would be a huge margin.
"The cost of a test (CHF180) will be reimbursed by basic health insurance as of Wednesday March 4, the health office announced."
Incidentally the information from China is little or no reinfection., little evidence for transmission before symptoms.
This isn't new - various similar methods have been used before over ~~ last 20 years. I wish them well but in my experience the molecule found is horrible. If it came out has a hit in a screen I'd discard it without looking back - in fact it would probably hit ~ 10-20% of all screens. Some of the others in the databases look far worst BTW.
2nd point is a hit - even if genuine - is not a drug. Safety, pharmacokinetics, distribution, and a whole lot of other requirements need to be met.
Still we'll see. We certainly need new 'antibiotics'
"But it is definitely not a desktop."
I too have a i7 and it has a much higher performance as might be imagined (for a laptop costing £650 5 or 6 years ago). But the Pi 4 is definitely usable as a desktop for modest tasks. As I mentioned earlier it will even video edit (using kdenlive), rendering the video takes about 4 times as long as on the i7. Playing 1080p50 video is very efficient with the built-in command-line player using the GPU (~~1% processor). and OK with vlc (~16%) from memory. I've run some processor intensive programs from my molecular modeling days and the drop-off is again ~ 4 fold from this machine. I have a multi-threaded script that converts a directory of RAW photos (~5K*4K pixels) into 1080, sharpened, jpgs for thumbnail purposes and it does that again about 4 fold slower - so I've given it some stick
Have you actually used one or are you going on specs. ? Mine hangs on the wall behind the monitor BTW. The other advantage you failed to mention is the price.
"none of them have had any issues"
Ditto ! Mind mine is in a rather nice cast-aluminium case/heatsink with a genuine hdmi cable.Very impressed fast enough for most (simple) desktop tasks. I've even video edited (1080p50) with mine & transcoded with ffmpeg (all cores working and temp ~65C.
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"If Flash is insecure, why does the BBC now insist I install Flash to get their podcasts or view catch up?"
They don't - I've not needed it for years.
Suggest you look at http://www.bbc.co.uk/html5
The exceptions are :
"There are some places where the HTML5 player won't work. These include:
Internet Explorer on Windows 8.1 or below
Safari on MacOS El Capitan or older"
(Some 3rd party content does need flash )
Let me be clear on this, at least for others. A catalyst only increases reaction rates (in either direction equally ) by lowering the activation energy. The system will reach its tthermodynamic equilibrium ( at the temp/pressure it's under) faster. It's a kinetic effect.
"Template-based modelling, however, only works if there is another well-known protein that is comparable"
However there are many in-between cases. One of the best ones I know are the prediction of the beta-propeller structure in integrins from other beta-propellers where the sequence match is rather poor.
"There's no Holy Grail, just a lot more work."
It would be nice to think there was but having spent 10+ years modeling proteins I tend to agree it's hard.
Incidentally the most important property of a sequence is probably to fold quickly and cleanly. Efficient function is nice to have.
"Dark matter has an effect on gravity, gravitational waves are a change or variation in/of gravity."
AFAIK gravitational waves distort spacetime and change lengths & time as they pass. They are not in themselves 'gravity'
A lot going on here so I've not been able to refresh my memory on this.
"Microwaved some coffee, put a spoonful of brown sugar in it, ,,, and WHOOSH"
It's essentially an example of kinetic v thermodynamic effect. Thermodynamically the water has enough ( more than ) energy to boil but no initiating pathway. In the lab we used little fragments of glass or wooden sticks ( added before reaching boiling I might add) to promote smooth boiling. Your sugar just trigger very rapid boiling. Almost like a mild explosion in fact. Cryogenic liquid gases added to room-temp water can sometimes behave in a similar manner - the initial turbulence promoting more and more rapid mixing until the evolution of gas become very violent.
"So it knows *where* it is, but it doesn't know how fast it's going? Or the other way around?"
But if it has a fixed position at time T and then T+x ( where x might be quite small) then the direction and travel are a trivial calc. That's what my hand-held GPS ( 14+ years old I'd guess) has always done.
"Does anyone use Linux on the desktop? </troll>"
Well I'm sitting here in Saas-Fee in Switzerland and I've just used a little GUI window on this Linux desktop to start downloading a number of BBC comedies onto a Pi at home (UK) . After that I'll move them using a GUI filemanager ( using fish: ) to watch here.
"12 people get shot in a school and it's the end of the world (which it is) but 3,000+ die EACH MONTH and it's completely ignored."
Difference is 12 people are shot without any reason WHATSOEVER whilst deaths on the road are one of the risks of everyday life (which we should try and minimize) for which we derive a benefit
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