Re: Monoliths?
Actually Clarke 2001 was set in the Saturnian system: the moon Iapetus specifically...
The move to Jupiter was made for the film 2001 with Kubrick and this continued in subsequent books. Interestingly there came the idea of life on Jupiter's moon Europa which is believed to host a sea under a thick shell of ice: water being the key ingredient for life.
In a bizarre twist that only the University could think of, turns out they could have stayed at Saturn with evidence for water (and organic compounds) at Enceladus...