Some design rules
Key tools are Anticipation and Imagination
To design for a 60 yr life, Decontamination & Decommissioning, start from the end, and work from the inside out.
IOW 1) Start from the design of the fuel package and how you take apart the finished NPP with minimal waste in a way that allows for maximum recycling of materials.
60yrs is a) 2/3 Pi x 10^9 Secs, 526K hrs or (from the US NRC) 500k PWR operating hours.
A few jet engines have managed 40K hrs while being entirely maintained on the wing of their aircraft.
Tilting pad bearing designs in hydroelectric power plants have lasted 50+ years.
So expect to operate, maintain and repair major sections of the plant over it's life. IOW design in access paths, clear lines of sight, hoists and monorails to move vessels about from day one (The "Digital twin" of the plant will be a vital part of the this process).
Gamma and neutron radiation are very bad for organic lubricants and all forms of insulation including the oxide layer in MOS transistors.
IOW keep all electrics and electrical sensors out of the core, and AFAP out of containment. Acoustic (sound waves can be in the 100s of MHz), optical, microwave and even mechanical are viable sensor options, which shaft, metal belt and compressed gas are all possible drive systems (NASA built a 1000Hp compressed air drive for testing high speed propellers in the late 70s/early 80's), with microwave heating for sintering fuel pellets.