Desktop Version OK, but...
(I thought) The original design was to mimic a red top tabloid, I assume that is why in landscape there are useless grey bands left and right. Could these unused areas of screen fulfil the mechanics of a web-page (navigation to the left) and (slow moving or static) advertising (to the right).
I am not sure you have to limit yourself to this metaphor, it is a web-page.
Don't have an ad at the top, then repeat it down the page, that just annoys. Although I want you to make the most money from your adverts. Perhaps you could have a classified ads section.
Basically there are landscape and portrait modes, with a roughly portrait content area.
In landscape the banner, navigation menu, and footer can slide to the left. And the equivalent to the leaflets that fall out of a newspaper to the right.
In portrait mode the banner and navigation menu reveal when you scroll up or stop scrolling for a few seconds.
The main content area, seems reasonable:
Big picture news story somewhere near the centre.
Top News big size, medium, small, small; top left
Most read just a list to the right
Latest news big size, medium, small... below
I don't think the categories (Data Centre, Software, Security, etc.) work, although the headline could be tagged with its category in small perhaps DC, SW, Sec, DO, Bus, PT, Sci, ET, BN, and Lec. Clicking on the section navigation would filter.