Re: Doo Beidou Beidou
Finding needles in haystacks is actually quite easy, if you have the right search and selection method. An automated conveyer belt and an electromagnet would suffice if the haystack can be dismantled.
If not a stronger magnet placed at various points around or above the stack and pulsed should also suffice. Or if the stack is entirely disposable set it on fire as you activate your magnet, helping the needle find its way out and onto the magnet.
Molecular biology has multiple means of finding needles in giant haystacks. I once did a dna ligation in building a transgenic construct which I worked out could come together again in at least 7 different configurations only one of which was desired. I put the result of the ligation in with a few million transformed bacteria and plated them on a growth plate with ampicilin in it. The dna plasmid had an amp resistant gene in it. You get little dots of bugs growing on your plate each the result of ONE bacterium with a plasmid in it.
You usually get from dozens to hundreds of spots. I got ONE and it was the right configuration. If your search committee has millions of members they get the job done. Needles in haystacks? all in a routine day's work in the biology lab.
In the molecular genetics lab we once formally worked out mathematically how many repeated patterns from individually Transgene injected eggs allowed to become embryos allowed you to conclude the patter was due to the sequences in the transgene and not because it inserted next to a genome control region. The assumption was that insertion in the genome was in essence random which is not absolutely true but true enough. The answer is 2. Because the genome is very, very, very large. We usually settled on 4.
These days knockout and transgene constructs usually have insulation sequences at either end so one would do.
It's a bit like dropping a needle into a haystack followed by another one. You drop them from high up so wind can affect the fall, you also swing the release mechanism in an arc. The bigger the haystack and the higher the mechanism and the more erratic the arc the chances of the needles coming to rest together are minuscule.