Non AMD compatible
The only piece of Enterprise software I know that does not run on AMD is SAP HANA, but this is purely an artificial limitation imposed by SAP (I have heard AMD themselves are running HANA on Epyc).
To get this market and in light of Intels delays, AMD really need to think about the 4 Socket market for very large memory foot prints e.g. larger than 8TB, where they can then also start competing with IBM and Power.
AMD have always been great innovators, first to dual core, first to SIMD instructions, first to integrated memory controller, and first to x86-64, I see the as a modern day digital/Sun. Great innovators not neseccarily good at execution/marketing but Lisa sure is turning that around.