Depending on the state if the lawyer knows that the person is likely to plead the 5th the jury must be cleared during questioning .
When a defendant pleads the Fifth, jurors are not permitted to take the refusal to testify into consideration when deciding whether a defendant is guilty. In the 2001 case Ohio v. Reiner, the U.S. Supreme Court held that "a witness may have a reasonable fear of prosecution and yet be innocent of any wrongdoing. The [Fifth Amendment right against self-incrimination] serves to protect the innocent who otherwise might be ensnared by ambiguous circumstances." This case beefed up an earlier ruling that prosecutors can't ask a jury to draw an inference of guilt from a defendant's refusal to testify in his own defense.