This is all well and good...
... but what does Kevlin think?
4 publicly visible posts • joined 31 Oct 2007
liver () {
AlcoholDehydrogenase(substrate) {
if (substrate == alcohol)
return acetaldehyde;
}
AldehydeDehydrogenase(substrate) {
if (substrate == acetaldehyde)
return acetic acid;
}
}
In heavy drinkers (this means you) the first function is a lot more efficient than the second, leading to a build up of acetaldehyde in the body when alcohol is consumed.
One way in which alcohol can become addictive is thought to be because acetaldehyde interacts with some neurotransmitters so as to mimic the effects of endorphins or opiates on the reward pathways of the brain, thus inducing a positive mood.
The boffins are suggesting that with his Aldehyde Dehydrogenase completely disabled by the drug, the hardened boozer would get his 'aldehyde high' from half a shandy, and thus not go on to consume the three bottles of vodka that would usually be required.