Computer says no!
I've had a couple of instances when I've had a PO to process and something has clearly been 'off' about it.
I've then checked with the requester and they've basically shouted back at me that "If I asked for 1000 units for testing, I mean 1000 units for testing!". I tried pointing out their likely mistake, but they were having none of it as they knew their job & product line better than me.
Luckily, I value my job more than their's, and as the order value would have triggered a further review anyway I contacted their line manager to double-check, who confirmed that it should have been '1 unit of a box of 1000' not '1000 units'...and was the MOQ for that item...and they needed them to test a new filling line.
I shudder to think what would have happened had 1000 boxes of 1000 items had turned up at their small filling operation - never mind the incoming QA/QC that it'd require.