Re: Nothing is ever new
"22L" would be a runway oriented at 220 degrees (where North is 0 degrees), and it's the left-hand one of a pair pointed that way. Similarly, "10L" would be the left-hand runway oriented to 100 degrees, and "7R" the right-hand one oriented at 70 degrees.
I *think* I recall a publicized event involving runway 22L at Boston's Logan International Airport, back in the 1970's. (Or maybe that's must my brain continuing to degrade.)