Security at the expense of usablity comes at the price of security.
Disabling a most useful tool is like never having a smartphone for fear of being robbed of it.
It should, of course, be an important part of defence-in-depth, part of active monitoring. "Twenty Powershell windows on a development machine with admin privileges? Probably okay, but one should stonewall the dev network from operations and finance. Single powershell process spawning out of the blue in the middle of accounting, where they only use ERP and Excel? Why? Let's take a look what's going on."
Funny, as I read an article or three to that effect several years ago. I thought Powershell would have been well understood by now. Why the sudden urge to comment on in, especially by a "random" group of five eyes states?