Most PCs from 2018 and beyond can theoretically run it, but many can't because they have various UEFI options disabled.
My Ryzen 2 PC was showing as incompatible until I switched from CSM/BIOS mode to UEFI, converted my boot drive from MBR to GPT, and enabled SecureBoot. It took a fair bit to do, and I doubt most people would bother. I expect most people to go to W11 when their next PC comes shipped with it.