Smalltalk-80
Xerox Parc machines could and did run Smalltalk-80 all the way down to the bare metal.
For a brief moment HP (nearly) had a pure Smalltalk-80 box running on a NatSemi 32032. I had a prototype to play with under NDA and for the time it was a rather fine, if specialist, workstation. However, it developed a hardware fault so they took it back on a Friday and by Monday HP had always been at war with Eastasia had never had a Smalltalk machine and never even considered developing such a thing. If it hadn't been for the h/w fault I might have managed to keep a non-existent HP ST-80 box as a home computer.