OS Updates
Users that actually want to get their work done being prevented by Windows deciding it's time to update - for an unknown duration. Literally £Billions on the table and nothing practical they can do. [1]
I've no doubt (too sceptical?) that that downtime will be increased as client OS and remote OS do their best to update at the most inconvenient times.
Also, how do you test a remote OS update before it's rolled out for you on your remote OS?
[1] I wasn't involved in desktop configuration, and I'm not sure what the company's policy was there re: updates during business hours. No doubt things have changed since W2000 regarding scheduling. But...