Left-handed rodents
I've always been a sinister mouser, simply because the first time I had a mouse for my machine (a Deskpro 386 as I recall), that was the side where I had space on my desk for a mouse.
Now I'm glad I learnt that way, as it leaves the right hand free for the number pad and so forth.
In other news, I still have a friend who uses her mouse with the cord facing away from her. It drives her coworkers mad, but it's how she started, and it's hard to unlearn many years of muscle memory.