Re: Trust Office
Yes there are differences. The browser PDF viewers are still catching up, and for non-RGB colors, gradients, blending etc. you're best off in Acrobat still. And form fields are the wild-west.
But for general text, I'd be pretty surprised if you had layout issues these days. Stuff like anti-aliasing, font hinting and so on is entirely the preserve of the PDF viewer, but putting a glyph at the right point on the page is fairly trivial.