The Bedlam DL3 email storm of 1997 did actually have an impact on mail server design. See Wikipedia and various first person accounts on the web,
There was another MS-related email storm last week when 3000 customers were sent an invite to an online webinar and instructed to reply-all. Cue hundreds of IT professionals sending "Unsubscribe" messages that added to the storm. Not a single one noticed that they had received N-1 unsubscribe requests that were the essence of the storm.