As somebody who switched from Windows to Apple several years ago, and is very happy with the way everything works together within the Apple orchard, it will be a right pain if Apple's native Mail app(s) can't cope. I've several email accounts that use 365 (one is for a charity and another an FE college) - around a dozen different accounts all (currently) play nicely together in the native iOS/MacOS Mail app. I have Outlook available but I find the simplicity of Apple's offering far better.
I initially bemoaned the fact, when leaving Outlook behind, that Apple's Mail, Calendar and Reminders apps were separate but, several years down the line, I've actually found keeping them separate works better for me. Mind you, it's helped a lot by the way iOS/MacOS keeps everything in order, in a way that Windows never seemed able to.