Duplicacy FTW
I used to use CrashPlan, but I won't touch proprietary backup systems ever again.
The replacement I now use is Duplicacy - which allows you to run your own servers, backs up to a wide variety of cloudy services, does cross-machine de-duplication, handles encrypted backups, and is open source. Development supported by donations and paid-for Windows GUI. Web GUI in development.
Biting the hand that feeds IT
