I often have two large TV's next to each other running the same game - one 1080p, one at 2160p. My eyesight isn't great but the difference in visual fidelity between the two is pretty apparent (even making allowances for differences in the panels - though there I'd be tempted to say that the 1080p panel is the nicer of the two!). That said these are quite a bit larger than your average gaming monitor so at smaller sizes the extra density might well be "wasted". I don't have the option with these displays but I might well opt for something like 1440p@100FPS over 2160p@60 FPS if I had the choice.