Common Problem
Running out of desk space to move the mouse is a common problem for me as my desk seems to be perpetually cluttered with "stuff" (rubbish??).
I have recently mitigated the problem by purchasing a trackball mouse: Since I no longer need to move the mouse, I just need to clear a space big enough to fit the mouse.
Needless to say, my manager, who is constantly hassling me to tidy my desk, was not impressed.