Re: Not by hand
"... and you've probably not heard of ..."
I am well aware of those things. You, perhaps, are unfamiliar with themes and styles in MS Word.
Also, perhaps, unfamiliar with the proverb: "The best is enemy of the good". MS Word and Libre Office Word can produce structured documents of office quality. If I want kerning and ligatures I will use Lyx or a 60-day trial I have of Quark Express.