What about Dorothy Hodgkin?
Awarded the Nobel Prize in Chemistry in 1964 for her determinations by X-ray techniques of the structures of important biochemical substances." -aka vitamin B12. Dorothy Hodgkin was a woman of great intellect and an immense passion for science, she helped advance the x-ray crystallography technique, which was the key to studying and understanding three-dimensional structures of biochemical compounds.
She also tutored and remained friends with Margaret Roberts (later Thatcher), but that is entirely incidental.