Re: Glossing a commercial turd
In the commercial passenger air business, passengers are already referred to - or at least thought of - as "self loading cargo".
The problem is, you can't slap a barcode or RFID tag on a passenger that they couldn't/wouldn't remove, lose or give to someone else, so all that automated cargo tracking that works so well for the manually loaded cargo is the bit that doesn't work for the self-loading stuff, so you have to keep checking that each piece of cargo really is the piece of cargo that the documentation it carries claims it is.
Also a box of auto components being shipped around the world cannot start having villainous thoughts and plan to bring down the plane or hijack it in order to fly to it's preferred destination of Maranello instead of the scheduled arrival at Dagenham (via Heathrow) or secure the relase of fellow auto components imprisoned in JIT parts bins in Sunderland.
If you could organise to collect passengers from their homes or designated pick-up points, verify their cargo papers at that point, place them in a secure container (from which they cannot leave) for delivery to the airport to be directly loaded on board, luggage and all then sure, that could work. You just need to have passengers willing to be treated even more like cargo than they already are.