"Let me know when all the spam is in your tar-pit rather than my inbox."
I'm achieving a 99.999% reject rate on my mailservers.
Unfortunately that still lets too much spam through and I have no idea if there's ham being refused _but_ when you team up the DNSBLs with fail2ban networks and friends you can prevent a lot of the bots even connecting.
That does nothing for abusive websites, though.