Win 7/Microsoft Security Essentials
I have several computers with different configurations, I have a Windows 7 machine running with Microsoft's Security essentials on it that already had this registry key set before the infamous update. Another computer with Windows 7 that has Trend Micro installed needed this registry key added.
(Trend Micro created a .reg file for users to download to add the key)
I don't know when the registry key on the Security Essentials machine was added but I know it existed before I installed the Meltdown update.