Assuming it was armed...
This should bring down a drone. Accurate home made machine gun. Twenty million hits! No wait a minute...
http://goo.gl/2b2UPg
I'd plump for employing one of our world class clay pigeon shots. Short range but likely a bit less collateral damage than say the million shot a minute Metal Storm,
https://youtu.be/wKlnMwuCZso