Hate Hate Hate
One thing that has always made me far angrier is when I'm clearly sad/angry/generally in a foul mood, and shunning most human company and some (I would assume well meaning) person notices and says something to the effect of "Cheer up! Smile!" without giving any reason for same or offering to assist in any meaningful way. Apparently you're just supposed to smile all the time or it confounds those whose emotional range only includes one or perhaps two moods.