I can add to that with a view from Pharma. we are a British firm selling chiefly into the British market. The 'magic' ingredient in our product (the active product ingredient) is made in Europe. We looked to see if we could get an alternative supplier in UK - have been quoted by a British company a stack of notes as tall as Boris-the-buffoon Johnson to develop a method to produce it. Not deliver a usable product but just to workup the method to produce the key ingredient.
Maybe they don't really want the work, or see us as an easy mark, but seems clear that costs of having the API made in UK is prohibitive.
Oh, and currently the API is turned into its final product form for us by European companies. Used to be by a British company but they all too often delivered it out-of-spec. Not going back there.