Moving to Vista wouldn't help (that also goes end-of-life in April) unless drivers/apps work in later versions of Windows.
There will be a lot of embedded systems with XP front-ends that just can't be upgraded - either they'll have to be completely replaced, or put through expensive recertification processes (to ensure that they're safe and producing reliable, reproduceable results) if they're upgraded - assuming the supplier is still in business.
Desktop stuff, I have less sympathy for...