It is not only over, it was always over
Had they been / if they are ruled against after all the appeals are exhausted, or congress stupidly passes a law to "fix" this situation, all Microsoft needs to do is create an Irish subsidiary to own the datacenters and be responsible for the data. That subsidiary would have a contract with Microsoft USA that allows Microsoft USA access to the data for their business purposes.
Heck, they could even go so far as to IPO that subsidiary in Ireland so Microsoft itself doesn't own any part of it. How could the US enforce its laws on an Irish company? What's next, try to enforce their laws on Irish pubs? The Irish company could just toss the subpoenas in the trash because the US would have no way to enforce them unless they want to stage a military invasion of Ireland.