Doing it carefully!
Until VirtualBox runs properly under W10 I'm definitely not shifting my main PC (currently on W7) onto it - hopefully it won't take Oracle more than 11 months to get it running properly again. I may use a spare hard disk and re-install a clean copy of W7 onto that and see what breaks when it upgrades to W10.
My laptop, which was running 8.1 (yuk!) that came pre-installed, upgraded almost ok - MS shoved the crappy, fail-after-reboot Wifi driver onto it so I had to reload the one that actually works and it now appears to be fine.