Re: I feel a vote coming on...
My Granny uses a mixture of exotic chemicals, fetal stem cells and witchcraft for anti-virus protection and, apparently, immortality.
For enterprise use I recommend a systems security chief with the ability to develop and enforce business friendly security policies and communicate the importance of good security practices to staff. If that person can't control the staff and manage pushy executives without the pushy executives knowing they are being managed they aren't ready to be selecting enterprise security products. If that person can do those things it doesn't matter what security product they choose, as long as they make it work.
System security is a staffing issue, not a technical issue. The only way to resolve staffing issues with technical measures is illegal almost everywhere and always results in carpet having to be replaced and walls painted.