Re: deeply modernising the Antonov 124 fleet
The An-124 is equally outdated and already four-engined, needing to be "deeply modernised", so the 225 would need to be as well. The Boeing 747 is an even older and less capable four-engined design. Their main virtue is speed of delivery, over a brand new design.
The current Western fleet of four whole An-125s is seriously inadequate to meet current supply needs. Quite what a major "modernisation" would be expected to achieve I don't know, but for NATO especially there is indeed a need for more and bigger, and sooner rather than later. The 225 design is ready and waiting, and easier to tool up than supergiant autoclaves. That deep mod would likely involve four modern engines.
But really, a fleet of the A350F is the obvious way forward, maybe with a nose door in later versions. I was/am as much lampooning the idea of wading into old stocks with an angle grinder and a reel of multimode fibre as making a serious proposal.
And of course, for the humorists among us, the 225 would offer an even bigger cache of bitbarn fillers.