Screen shot, then hide the desktop icons
Back in the late 90s, early 2000s, we had lots of Windows boxes, mix of NT, 2k and 95 (for some old DOS apps that didn't like NT).
We also had a policy of lock-if-away, which was often ignored.
If it was my turn to hold the fort at lunch time, and had nothing better to do, I'd wander round the open plan office, although only in the bays for our team, maybe 30 desks, looking for any unlocked machines.
If I found one, I'd take a screen-shot of the desktop, create a new folder on the desktop and drop any other desktop icons into this new folder, then rename that new folder to something like My Documents, or to match something that had already been on the desktop.
I'd then set the wallpaper to the previously created screen-shot, set the task bar to auto-hide, and if needed move the previously created folder so it blended in with the new background.
On return, you'd have people plugging in a different mouse because clicking didn't work, rebooting, the occasional rude word etc. Before figuring out what was up.
Happy days.