back to article Wastewater monitoring project could catch next pandemic early, says health agency

The UK Health Security Agency is looking to set up an early warning system ahead of future pandemics, launching a £1.3 million (around $1.75 million) program to identify "cutting-edge technologies" which could turn people's pee and poop into valuable data on the spread of viruses. "Wastewater monitoring has the potential to be …

  1. elsergiovolador Silver badge

    Truffles

    Ah yes, the brave new world of bio-surveillance: ‘According to our wastewater AI, Mr Jones pooped truffles today, yet his bank statement shows no Fortnum & Mason purchases. Possible undeclared income. Alert HMRC.’

    1. Doctor Syntax Silver badge

      Re: Truffles

      Oh, how quickly we forget.

    2. headrush

      Re: Truffles

      Given the immense difficulty the incumbent water authorities have with getting the sewage to the treatment plants instead of open waterways, I have a hard time believing they would be able to trace any particular turd to a specific town, let alone a specific toilet in a specific building used by a specific person.

      Unless your weetabix contains tracking chips of course....

      1. elsergiovolador Silver badge

        Re: Truffles

        You’re assuming everyone gets treated the same. This is Britain: water companies can dump raw sewage straight into rivers and the sea and walk away with record bonuses, but if a single peasant lets a paper bag blow down the high street the fine’s in the post before it hits the gutter. Surveillance isn’t about catching every turd - it’s about reminding you which end of the pipe you’re on.

    3. Anonymous Coward
      Anonymous Coward

      Re: Truffles

      Yes your honour I found the truffles under a tree. ;)

      1. TimMaher Silver badge
        Coat

        Re: Truffles

        Porky, is that you?

  2. ParlezVousFranglais Silver badge

    £1.3 million - great, so £1.25 million on Management Consultants, Lawyers, Accountants and HR, and £50k spent on the actual proposal which will consist of 3 interns asking AI for information related to these "cutting-edge technologies" and then asking AI to turn the resulting waffle into some pretty slides, and then asking AI how best to cut corners to reduce the overall price of any solution that is proposed (regardless of the fact of course that before anybody bothered checking the AI came up with anything actually workable, they ran out of budget).

    I'm sure the outcome will be a marvel to behold...not that I'm a cynic or anything...

  3. Doctor Syntax Silver badge

    It seems an eminently sensible thing to do. Even with advanced tech public health is always the leased glamorous aspect of health care and yet the most important. Ideally it might be possible to identify sequences which seem to be evolving towards pathogenicity and even start working towards RNA vaccines for them.

    1. Doctor Syntax Silver badge

      "Eminently sensible" doesn't seem something you can attribute to the US's public health olicy: https://www.bbc.co.uk/news/articles/cwy3zjxy3dwo

      1. jake Silver badge

        "Eminently sensible" as a concept is temporarily on hold in Washington DC.

        The mid-terms are coming.

        And the senior citizen in the oval office's mind seems to have left the building ... Shirley the republican faction can't continue their charade much longer.

    2. Charlie Clark Silver badge
      Thumb Up

      AFAIK the Netherlands, which developed the system, and Germany still use it because it was so cost effective. I think it's helped identify reactivated Polio from people coming from Africa. In fact, comparative studies showed it was much better at detecting outbreaks early than the much more onerous and expensive self-testing systems, not to mention the "track and trace" nonsense.

      Also, in Europe, the police, etc. need a court order to access the data assuming they want to localise illicit chemical labs.

      1. DS999 Silver badge

        At least in the US they sample at the treatment plant, so there wouldn't be any way to localize beyond that using the infrastructure set up for COVID. I'm not aware of any legal prohibition to the police sampling neighborhood sewer lines, I imagine waste is considered "abandoned" and open to search without a warrant once you flush it down the toilet / pour it down the drain in the same way trash is considered abandoned when you leave it on the curb for pickup.

        1. jake Silver badge

          Also in the US, we've been analyzing wastewater for viruses & etc. for many decades (1960s (for polio), some early experiments go back to the '50s). It's a known, fairly low-cost technology that works.

          Yes, the authorities could probably narrow it down to the exact street of origin, and then go door-to-door until they found the source ... but the cost would be horrendous in both money and political ill-will.

  4. Dr Dan Holdsworth
    Boffin

    You find what you search for

    The problem with going looking for environmental DNA and RNA is that these markers are very specific to the pathogens you're looking for. That means that this form of monitoring only detects levels of known pathogens and not unknown ones.

    A better sensing system would be to include monitoring of levels of human cytokines in the waste water, to see if the population in general is doing more immunologically than normal. This would indicate a new disease is activating peoples' immune systems, and if you start seeing high levels of cytokines associated with viruses or infections but you do not see increases in the specific e-DNA and e-RNA that you're also monitoring, then you have got an unknown pathogen on the loose.

    Or maybe not. I don't think anyone has done any monitoring of wastewater cytokines before, so in doing so you'd be breaking new ground and might see some quite surprising results.

    Wastewater monitoring of illegal drug metabolites was another world first that provided a slew of new and unwelcome results. It tallied with normal sanity checks in that people took more drugs at the weekend than during the week, but it also indicated that a small multiple of the tonnage of drugs that the police and Customs had guesstimated was being used was turning up in wastewater. This is why you don't hear much about wastewater drug testing anymore; it paints Customs and the police in even more of a useless light than they are normally viewed in, since the amount of illegal drugs that they are not detecting is much, much higher than their supposedly informed guesses.

    This testing also established that there are a lot more drug users in the country than was previously thought, and that most of them are perfectly capable of taking illegal drugs and not sliding down into a dependency death spiral. Evidence like this strengthens the position of folks like Prof Nutt, who advocates for drug legalisation.

    1. MonkeyJuice Silver badge

      Re: You find what you search for

      That's definitely an interesting idea, although how stable are cytokines? IIUC they're fairly weedy little proteins, and effluent is full of hungry, hungry organisms. Would they be recognisable by the time they reach the monitoring site?

    2. Doctor Syntax Silver badge

      Re: You find what you search for

      It should be possible to identify sequences typical of broad groups of viruses and look for variations.

      1. Korev Silver badge
        Boffin

        Re: You find what you search for

        Exactly, this is the metagenomic sequencing they mention in the article

    3. Sam not the Viking Silver badge
      Pint

      Re: You find what you search for

      There's obviously a lot of interesting (?) stuff in sewage. The tracking of specific diseases goes on but also there is a general interest in bacteriophages which develop in sewage. It's not as glamorous as 'Pharmaceutics'.

      But where there's muck, there's brass.

      Another bio-hazard suitable for processing and conversion, requiring investment -->

      1. Charlie Clark Silver badge
        Thumb Up

        Re: You find what you search for

        And resistance to antibiotics… considered to be one of the possible side-effects of outsourcing production to countries with less stringent environmental controls.

    4. elsergiovolador Silver badge

      Re: You find what you search for

      The trouble is, people still think the ‘war on drugs’ is about protecting them from harm. It isn’t. It’s a managed theatre: a controlled black market kept illegal not to stop supply, but to ensure it flows through the right invisible channels. If it were legal, the money would be traceable, taxable, accountable - instead, it’s laundered into property, politics, and finance.

      Because it’s ‘illegal,’ the whole market is structurally violent. Gang can’t exactly take opps to small claims court for unpaid shipment, so disputes are settled with knives and guns. Customers have no consumer rights, so every rip-off or contamination spirals into more conflict. That manufactured violence doesn’t just scar communities - it fuels entire cottage industries: charities, think tanks, police task forces, prison contractors, even pharmaceutical giants who make billions flogging antidepressants and anxiety meds to the families left picking up the pieces.

      The police aren’t dismantling the trade - they’re managing its margins: keep the street dealers harassed, keep prices inflated, keep the market opaque. And always, always make sure the stop-and-searches happen on estates, never in Kensington or the Square Mile. The facade is ‘public health’ and ‘safety.’ The reality is a state-sanctioned black market whose violence is not a bug but a feature, enriching the very system that claims to fight it.

      Sacking of Prof Nutt, only proves the system works as intended.

      1. Anonymous Coward
        Anonymous Coward

        Re: You find what you search for

        The police aren’t dismantling the trade - they’re managing its margins: keep the street dealers harassed, keep prices inflated, keep the market opaque.

        Pretty much the story line of the BBC's The Shadow Line (2011) with the added twist the sale of the trafficked narcotics financed the police pension fund.

    5. DS999 Silver badge

      Re: You find what you search for

      No one is suggesting you can find novel outbreaks this way. They're saying it is a much faster and more accurate method of judging spread than by testing. Covid nasal testing fell short because early on there was a huge shortage of test kits, then once they were widespread it was still limited to the people getting tested which is not a representative sample.

      Wastewater testing means you only need to do one (or a small number of) "test" per day for a whole city so you could start far earlier in a pandemic, before mass production of test kits ramp up. It doesn't tell you who is sick, or how many people are sick, but if you saw the levels doubling every few days early on in a pandemic you'd get advance notice something bad is happening.

      Imagine if it was standard procedure for cities to collect samples and send them off to state/national labs for testing. Even if they didn't start testing US samples for covid until March when it became apparent this wasn't just going to blow over, they'd be able to retest older saved samples to see the timeline and determine where and when it first reached the US. If everywhere did this, you could pinpoint where an outbreak originated, or at least where it began to spread enough to show in high enough levels for wastewater testing to see.

      1. elsergiovolador Silver badge

        Re: You find what you search for

        you only need to do one (or a small number of) "test" per day

        This is the problem right there.

        How decision makers can get their kickback worth their time from such setup?

        The split of profit probably wouldn't even buy a holiday in Barts.

        1. druck Silver badge

          Re: You find what you search for

          You are getting really boring, give us all a break.

          1. elsergiovolador Silver badge

            Re: You find what you search for

            Corruption only feels boring once it’s normalised.

        2. TimMaher Silver badge
          Headmaster

          Re: “holiday in Barts”

          Or St. Bartholomew’s Hospital.

          To give it its full name.

  5. segfault188
    Pirate

    cutting-edge technologies

    The term "cutting-edge technologies" is supposed to sound impressive, but it actually refers to the spinning blade that chops up the turds so they can be analysed by an AI-enabled sniffer.

    Please don't poo-poo the explanation.

  6. jokerscrowbar

    Brave New Turd

    I’d be impressed if it weren’t for the fact that they have already been doing this for years and that funding for the existing monitoring stations has actually dropped significantly.

    1. DS999 Silver badge

      Re: Brave New Turd

      I assume that's why they are trying to point out the advantages of testing, to justify keeping the rather moderate funding the ongoing collection requires. Heck the US might need to start testing wastewater for measles soon with RFK Jr in charge.

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