Fun stuff
"greater economies of scale, more efficient manufacturing, and improved quality and scale" is something you also get with all that 48V stuff that comes from telecoms and automotive already.
Going for 400V/800VDC as a next step just means you can continue to benefit from some of that scale.
Upside of going 400VDC & up is you don't need quite such ridiculously oversized conductors & connectors, though they'll still be substantial at the power levels involved & might even need plenty of cooling too. Big downside is how solidly hazardous a DC supply at that voltage is in multiple ways & will require some serious safety design & changes to working practices.
The other comical bit is going to be cooling the equipment at that power density, it's not exactly trivial. There's one or two fun examples from old compact supercomputer projects (taking an existing design and making it deskside sized for deployment into flying/floating use), and I've done testing myself with kit that needed ridiculously sized coolant feeds to extract the energy; amazingly easy to heat a full flow full bore watermain if you dump enough power into it. The cooling system will probably end up as a serious hazard in itself.
Maybe the better option is to accept density limits and not chase into the realm of silly engineering requirements and safety hazards?