Another vote for Proxmox
I've had proxmox in production now for close to two years in three different deployments and I'm about to deploy the fourth.
First was a 3 node cluster with 240 cores & 512Gb per host. Storage was via iSCSI to an all-flash Synology array over 2 x 10Gb ethernet links. Absolutely rock solid performance, stability and usability, the only annoyance was upgrades weren't as easy as they could have been but it was an annoyance rather than a problem.
Second was a smaller 3 node cluster with 32 cores & 512Gb per host. That one used converged storage with SSD's in each server providing a total of about 60Tb of CEPH-backed storage. We segregated the storage network on 25Gb ports and kept the VM's on 10Gb ports. Also absolutely rock solid and very high performing. CEPH took a bit of getting used to but again, once done it just worked.
Third came a four node cluster distributed across four different DC's. 32 cores/512Gb per host, 10Gb/sec interconnects with 25Gb/sec for storage and again, a CEPH array of NVME disks totalling 40Tb. That particular cluster survived a complete DC failure without missing a beat...
Currently, I'm working on a new cluster which will have 3 hosts with 192 cores per host, 768Gb RAM and 60Tb of storage per host.
All of those have used Proxmox's own backup solution and it's never been a problem. Fast, reliable backup, very efficient on disk storage (the dedupe is amazing) and good alerting for failed/completed backups. I target the backups to Synology NAS's and use Synology's replication, snapshot & immutability to replicate & protect the backups. As a last resort there is also an offsite replica that's managed via Proxmox Backup - we should never need it but it's nice to know it's there!
All in, I'd highly recommend Proxmox. In licence costs alone it's saved me tens of thousands, never mind the lower cost of hardware achievable by using CEPH.
VMware and Hyper-V should be worried. Very worried.