Plus ca change - lentement
Nope in 2047 Windows 25 will be sporting slightly sharpened corners, IBM Red will be run as a service and the Linux world will still be divided between GT & GTK.
The first 50 years of aviation took us from the bi-plane to the 747. The next 50 years took us from the 747-100 to the 747-800. Fast moving stuff can head in only one direction - slower. As it becomes established people change from wanting change to no change.
What will probably happen is 'desktop computing' will go niche with everything else using more 'handy' devices where gesture and sound may be the chief inputs. TheRegister will become the new Saga magazine for care home techies hacking their health monitors and their BBC Netflix account.
I'll soon be a pathfinder with time to maybe escape from systemd.