Re: A silly idea from a silly person...
What if I gave an RPi4 32Gb of RAM, a 240Gb SSD, and wanted to use it as a dayly driver
The flaw in this scenario is that you can't give a Pi 32GB of RAM. Currently they come with 1, 2, 4 and 8GB - if you can find them at all - and it's soldered-on.
(Cheeky aside - of course if you did mean 32 gigabits, then yes, you can buy a Pi with 4 gigabytes)
On a more serious note, I think for most general tasks a Pi 4 would be acceptable, particularly with 4GB or 8GB RAM and some kind of cooling solution. My boys used a Pi 3 with 1GB RAM for general homework tasks (OpenOffice), web browsing and some light YouTube watching for a couple of years, though they did have access to a "proper" computer as well (files on a NAS so could be accessed from either). 1GB did make the browser "page out" quite a lot (not literally paging as there's next to no RAM cache and default installs come with (IIRC) a 100MB swap file on the slow SD card), meaning parts of pages had to be reloaded if you switched tabs or scrolled, and OpenOffice did struggle a bit if they tried to create presentations with lots of photographs or large graphics, but for essays, simple presentations, email and browsing for example BBC News or The Register it was just fine.
Trying to take the question seriously, so apologies if it was meant in jest, but just in case not, it's also worth bearing in mind that the only way to attach external storage (that is, other than the SD card it boots from) to a Pi is through USB, and while the Pi 4 has USB3 it's never going to be lightning fast.
As for a screen reader - not my field. If you are paying for a commercial solution that only runs on Windows, then I'm afraid the Pi doesn't do Windows either.
Interesting thoughts though.