monitor CPU usage too
Several years ago I was called in to help with another team's compromised Wordpress website. At the time it was infected with a bitcoin mining thing. The only reason it was detected was because it shot cpu usage through the roof, which then tripped some alarms I think. Of course the system was lacking many updates which led to the compromise, but the point being crypto miners being installed I would expect CPU usage to go way up.
On all of my ~800 VMs I have monitors that say if CPU usage(as measured by vCenter, monitored by Logic Monitor) is greater than 75% for an hour then send an WARNING alert, if greater than 90% for an hour send a CRITICAL alert (neither alert goes to pagers just to pager duty alert dashboard and email). Not to track crypto currency miners of course just general usage indicating something could be wrong with the software running on the system if it is using CPU for that long.
It's pretty rare on my systems at least that the CPU would be pegged for more than an hour for a normally functioning application(I guess if that was normal then it would signal to me that the system needs more CPU resources), though it does happen from time to time.