Play By Email.
Even before the lockdown made in person table top gaming impossible, my friends & I got into the PBE style to accommodate all the different schedules of the folks playing. You still have the DM, PC's, & NPC's, adventure hooks, trips, traps, treasures, & terrors, it's just played at a pace that leaves each person time to craft their turn description as their schedule permits.
DM sends a group email with the current situation description, exactly the same as if everyone were at the table. You are given one week in which to think about what you want to do, describe it in detail, & email back to the DM. Player's can side-talk to each other to brainstorm strategy & coordinate, but everyone separately & individually replies to the DM with their PC's actions. The DM collects all the replies, collates & coordinates what happens, asks individuals for specific dice rolls, then releases another "Current Situation" update (the start of the next Round.) Players can post In Character (IC), Out Of Character (OOC), and include any dice rolls they know the DM will need so as to speed things up a bit, but otherwise it's a game of table top D&D just at a more leisurely pace.
It's a great way to be inclusive & accessible to disabled players, since they get all the action via plain text that can be consumed in the same way they get their email.
There's no issues with video programs trying to live stream a game that may need Sign Language for the deaf or an audio transcription for the blind, there's no pressure for those with motor skill impairments to rush to post in a severly limited amount of time, and you can even play when all you can manage is a crappy dial up connection to a monochrome green screen of blargh.
Granted the DM may need to Save As plain text any/all PDF's for offering to those of us that can't read the pretty pictures, but that's a small price to pay to get the DM a batch of easily searchable plain text files through which to quickly find the bits they need. As an example, I've got all my stuff in plain text spread across various subdirectories such as Backgrounds, Classes, Domains, Items, Races, Rules, Spells, Tables, Wild Magic & Surges, etc. I can jump to the proper directory, find the proper file, & do a Control+Find to get the data I need so I can create the next Current Situation Email (CSE) to keep the game going. I have a directory for Characters further subdivided into each Class, so if I need a Cleric for example, it's D&D>Characters>Clerics & browse the list until I find one that works for what I need.
PBE isn't just a "disabled person" thing, it's open & available for any/everyone. If you want to play a non-video-call version that doesn't require a constant internet connection, or a game that doesn't require everyone to coordinate schedules in order to play, PBE is the way to go. =-)