If you don't like apps touching, Qubes 4.0.1 is a good place to jump in

Invisible Things Lab pushed out a point release of Qubes OS this week in the form of version 4.0.1 The update, which is effectively a convenient roll-up of the changes made since March 2018's release of version 4.0, arrived on 9 January. It also includes template VM updates for Debian 9, Fedora 29 and Whonix 14. If you've …

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Qubes is lovely indeed but it feels a bit sluggish on less than serious hardware. A fast SSD connected through NVMe rather than SATA is particularly recommended - plus copious RAM, obviously.